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Similar to Nanai's Drop Mania (Game) games but using the Rampagelicense, multiple colored blocks are lowered by the player after arranging them in a row to wipe out an area of blocks at the bottom of the screen. Once all blocks are cleared from the bottom, the level is finished. As the player moves the blocks, the chosen Rampage character is shown climbing up and down the side of the puzzle area. At the end of each level, the player is scored based on multiple factors including time to complete, chains and combos, and best chains and reactions.
The four different modes in single-player include: Clear, Puzzle, Rescue, and Marathon.
The three different modes in two-player include: Rescue, Score, and Attack.
In Clear, Puzzle, and Rescue, there are a set number of levels in different locations from around the globe (and above it!). The areas, in order, are Tokyo (Location), Dehli, Helsinki, Paris (Location), Hollywood (Location), Washington D.C., Moscow (Location), Area 51 (Location), and, finally, Outer Space. Each area comprises five levels for a total of 50 levels in each of the Clear, Puzzle, and Rescue modes.
The game starts with the original trinity from Rampage to choose from: George, Lizzie, and Ralph. After beating certain levels in Puzzle mode, other characters from the series are unlocked.